Darwin’s Dice –“Origin of Life was Non-Biological”

Origin of Life


“Modern metabolism has a precursor, a template, that was non-biological,” says biochemist Greg Springsteen at Furman University.

“The Tape of Evolution Would Probably Arise Again in Distant Worlds”

Biologist Charles Cockell, author of The Physics of Life, said that rerun the tape of evolution, and DNA, RNA, ATP, “the Krebs cycle — the rigmarole of Biology 101 — would probably arise again in distant worlds. Single cells would then join together, seeking the advantages of metazoan life, until before you know it something like the earthly menagerie would come to be.”

“I would agree with Cockell that certain general features could emerge on other worlds,” wrote astrobiologist Manasvi Lingam at Florida Institute of Technology in an email to The Daily Galaxy. “We can, for instance,” he continues, “expect polymers that carry information (analogs of RNA/DNA), polymers that aid in catalysis (like proteins), and so on to emerge. Likewise, if the conditions permit, the origin of multicellular organisms is feasible because of the advantages conferred by the latter. And similar considerations apply to the origins of what is known as complex multicellularity (e.g., plants and animals). On the other hand, not every world is guaranteed to host complex life. And even if complex life exists, it need not resemble Earth-based life in all respects.”

Chemistry Opens the Black Box

In 2018, chemists at The Scripps Research Institute (TSRI) developed a fascinating theory for how life on Earth may have begun. Their experiments, described in the journal Nature Communications, demonstrate that key chemical reactions that support life today could have been carried out with ingredients likely present on the planet four billion years ago.

“This was a black box for us,” said Ramanarayanan Krishnamurthy, associate professor of chemistry at TSRI and senior author of the new study. “But if you focus on the chemistry, the questions of origins of life become less daunting.”

Citric Acid Cycle

For the study, Krishnamurthy and his coauthors, who are all members of the National Science Foundation/National Aeronautics and Space Administration Center for Chemical Evolution, focused on a series of chemical reactions that make up what researchers refer to as the citric acid cycle, also known as the Krebs cycle.

Every aerobic organism, from flamingoes to fungi, relies on the citric acid cycle to release stored energy in cells. In previous studies, researchers imagined early life using the same molecules for the citric acid cycle as life uses today. The problem with that approach, Krishnamurthy explains, is that these biological molecules are fragile and the chemical reactions used in the cycle would not have existed in the first billion years of Earth—the ingredients simply didn’t exist yet.

Leaders of the study started with the chemical reactions first. They wrote the recipe and then determined which molecules present on early Earth could have worked as ingredients.

Two Non-Biological Cycles

The new outlines how two non-biological cycles—called the HKG cycle and the malonate cycle—could have come together to kick-start a crude version of the citric acid cycle. The two cycles use reactions that perform the same fundamental chemistry of alpha-ketoacids and beta-ketoacids as in the citric acid cycle. These shared reactions include aldol additions, which bring new source molecules into the cycles, as well as beta and oxidative decarboxylations, which release the molecules as carbon dioxide (CO2).

Evolution of Molecules

As they ran these reactions, the researchers found they could produce amino acids in addition to CO2, which are also the end products of the citric acid cycle. The researchers think that as biological molecules like enzymes became available, they could have led to the replacement of non-biological molecules in these fundamental reactions to make them more elaborate and efficient.

“The chemistry could have stayed the same over time, it was just the nature of the molecules that changed,” says Krishnamurthy. “The molecules evolved to be more complicated over time based on what biology needed.”

Making these reactions even more plausible is the fact that at the center of these reactions is a molecule called glyoxylate, which studies show could have been available on early Earth and is part of the citric acid cycle today (called the “Glyoxylate shunt or cycle”).

Krishnamurthy says more research needs to be done to see how these chemical reactions could have become as sustainable as the citric acid cycle is today.

The Daily Galaxy, Avi Shporer, Research Scientist, MIT Kavli Institute for Astrophysics and Space Research via The Scripps Research Institute. Avi was formerly a NASA Sagan Fellow at the Jet Propulsion Laboratory (JPL).

Image credit: Shutterstock License


THe Galaxy Report

Your free twice-weekly fix of  stories of space and science –a random journey from Planet Earth through the Cosmos– that has the capacity to provide clues to our existence and add a much needed cosmic perspective in our Anthropocene epoch.

Yes, Sign Me Up for “The Galaxy Report” Newsletter