“Molecular Machines” — Proof of Evolution at Cellular Level

Mechanical_molecular_machines

"Our cells, and the cells of all organisms, are composed of molecular machines. These machines are built of component parts, each of which contributes a partial function or structural element to the machine. How such sophisticated, multi-component machines could evolve has been somewhat mysterious, and highly controversial."

Trevor Lithgow of Australia's Monash University.


An international team of biochemists have discovered evidence at the molecular level in support of one of the key tenets of Darwin's theory of evolution that provides a blueprint for a general understanding of the evolution of the "machinery" of our cells.

"Our research shows that these machines although complete and complex, were a result of evolution. Simple ''core'' machines were established in the first eukaryotes by drawing on pre-existing proteins that had previously provided distinct, simplistic functions" -proof that Darwin's theory of evolution is valid at the molecular level, Professor Lithgow added refuting non-Darwinian explanations of Intelligent Design that propose that these complex machines to be so "irreducibly complex" that they must have been designed by an intelligent entity.

As a model system, the research focussed on one specific molecular machine, the TIM complex, which transports proteins into mitochondria. Mitochondria are a compartment of human cells that serve as the energy-producing 'powerhouses'. At a very early stage in evolution, mitochondria were derived from bacteria that lived within the first eukaryotic cells.

"Our cells literally are chimeras of a "host" cell and these intracellular bacteria. Yet bacteria don't have TIM complexes – to understand where the TIM complex came from we simply applied scientific reasoning and looked at a modern-day bacterium akin to the organism that gave rise to mitochondria." Professor Lithgow said.

The group looked at the bacterium Caulobacter crescentus and found bacterial proteins related to the components of the mitochondrial TIM complex. They then showed that these bacterial proteins are not found as part of protein transport machines.

"François Jacob described evolution as a tinkerer, cobbling together proteins of one function to yield more complex machines capable of new functions." Professor Lithgow said.

"Our work describes a perfect example of Jacob's proposition, and shows that Darwin's theory of evolution beautifully explains how molecular machines came to be."

Casey Kazan via Monash University

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